Download MendeleyStructural landscape of activation, desensitization and inhibition in the human TRPM4 channel
Teixeira-Duarte, C.M., Zeng, W., Jiang, Y.(2025) Nat Struct Mol Biol
9MT8 | pdb_00009mt8
Cryo-EM structure of the human TRPM4 channel in a calcium bound putative desensitized state
- PDB DOI: https://doi.org/10.2210/pdb9MT8/pdb
- EM Map EMD-48603: EMDB EMDataResource
- Classification: TRANSPORT PROTEIN
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2025-01-10 Released: 2025-10-29
- Funding Organization(s): Howard Hughes Medical Institute (HHMI), National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Welch Foundation
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.19 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transient receptor potential cation channel subfamily M member 4 | A [auth D], B [auth A], C [auth B], D [auth C] | 1,214 | Homo sapiens | Mutation(s): 0 Gene Names: TRPM4, LTRPC4 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8TD43 (Homo sapiens) Explore Q8TD43 Go to UniProtKB: Q8TD43 | |||||
PHAROS: Q8TD43 GTEx: ENSG00000130529 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8TD43 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CA (Subject of Investigation/LOI) Query on CA | E [auth D], F [auth A], G [auth B], H [auth C] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.19 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.21.2_5419 |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-10-29 Deposition Author(s): Teixeira-Duarte, C.M., Jiang, Y.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Howard Hughes Medical Institute (HHMI) | United States | -- |
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | R35GM140892 |
| Welch Foundation | United States | I-1578 |
Revision History (Full details and data files)
- Version 1.0: 2025-10-29
Type: Initial release
